Through her work with homeless youth, Dr. Rotheram became interested in the HIV/AIDS epidemic in 1987. For the past 30 years, much of her research and work has focused on reducing the global burden of HIV, particularly in mothers, children, and other vulnerable populations. In 1995, she established the Center for HIV Identification, Prevention, and Treatment Services (CHIPTS). The center now coordinates and supports the work of over 43 research scientists conducting HIV programs around the world.
Dr. Rotheram has been involved with HIV prevention research in the United States, Thailand, China, Uganda, South Africa, India and Vietnam. Many of her interventions have been designated model programs and have been broadly implemented.